The effects of flaxseed dietary supplement on lipid
profile, bone mineral density, and symptoms in menopausal women: a randomized,
double-blind, wheat germ placebo-controlled clinical trial
Dodin
S, Lemay A, Jacques H, Legare F, Forest JC, Masse B ; Clin Endocrinol
Metab. 2005 Mar;90(3):1390-7
Flaxseed Dietary Supplement Versus Hormone Replacement
Therapy in hypercholesterolemic Menopausal Women
André
Lemay, MD, PhD, Sylvie Dodin, MD, MSc, Nadine Kadri, MD, Hélène Jacques, PhD and
Jean-Claude Forest, MD, PhD; Obstetrics & Gynecology
2002;100:495-504
Breast Health
The inhibitory effect of flaxseed on the growth and
metastasisof estrogen receptor negative human breast cancer xenograftsis
attributed to both its lignan and oil components
WangL, Chen J, Thompson LU. Int J Cancer. 2005 Apr 22; (Epub ahead of
print)
Dietary flaxseed alter tumor biological markers in
postmenopausal breast cancer
Thompson LU, Chen JM, Li T,
Strasser-Weippl K, Goss PE; Clin. Cancer Research 2005 May,
11:3828-3835
Supplementation with flaxseed alters estrogen metabolism
in postmenopausal women to a greater extent than does supplementation with an
equal amount of soy
Jennifer D Brooks, Wendy E Ward, Jacqueline
E Lewis, John Hilditch, Leslie Nickell, Evelyn Wong and Lilian U Thompson;
American Journal of Clinical Nutrition 2004;79:318-325
Mammary gland morphogenesis is enhanced by exposure to
flaxseed or its major lignan during suckling in rats
Tan KP,
Chen J, Ward WE, Thompson LU; Exp Biol Med (Maywood)
2004;229(2):147-57
Exposure to flaxseed or its purified lignan during
suckling inhibits chemically induced rat mammary
tumorigenesis
Chen J, Tan KP, Ward WE, Thompson LU;
Exp Biol Med (Maywood) 2003 Sep;228(8):951-8
Effects of Dietary Flaxseed in Women with Cyclical
Mastalgia.
Goss PE, Li T, Pinto S, Thompson LU; Breast Cancer
Res Treat 2000; 64:49
The effect of flaxseed and wheat bran consumption on
urinary estrogen metabolites in premenopausal women
Haggans CJ,
Travelli EJ, Thomas W, Martini MC, Slavin JL.; Cancer Epidemiology
Biomarkers & Prevention 2000;9:719-725
Plasma insulin-like growth factor I levels in rats are
reduced by dietary supplementation of flaxseed or its lignan
secoisolariciresinol diglycoside
Rickard SE, Yuan YV, Thompson
LU; Cancer Lett. 2000 Dec 8;161(1):47-55
Exposure to flaxseed or purified lignan during lactation
influences rat mammary gland structures
Ward WE, Jiang FO,
Thompson LU; Nutr Cancer 2000;37(2):187-92
Effect of flaxseed consumption on urinary estrogen
metabolites in postmenopausal women
Haggans CJ, Hutchins AM,
Olson BA, Thomas W, Martini MC, Slavin JL.; Nutr Cancer
1999;33:188-195
Exposure to flaxseed or its lignan component during
different developmental stages influences rat mammary gland
structures
Tou JC, Thompson LU; Carcinogenesis 1999
Sep;20(9):1831-5
Dose effects of flaxseed and its lignan on
N-methyl-N-nitrosourea-induced mammary tumorigenesis in
rats
Rickard SE, Yuan YV, Chen J, Thompson LU; Nutr
Cancer 1999;35(1):50-7.
Flaxseed and its mammalian lignan precursor cause a
lengthening or cessation of estrous cycling in rats
Orcheson LJ,
Rickard SE, Seidl MM, Thompson LU; Cancer Lett. 1998 Mar
13;125(1-2):69-76
Antitumorigenic effect of a mammalian lignan precursor
from flaxseed
Thompson LU, Seidl MM, Rickard SE, Orcheson LJ,
Fong HH; Nutr Cancer 1996;26(2):159-65
Bone Health
Flaxseed improves lipid profile without altering
biomarkers of bone metabolism in postmenopausal
women
Lucas EA, Wild RD, Hammond LJ, Khalil DA, Juma S,
Daggy BP, Stoecker BJ, Arjmandi BH; J Clin Endocrinol Metab.
2002;87(4):1527-32.
The role of phytoestrogens in the prevention and treatment
of osteoporosis in ovarian hormone deficiency
Arjmandi BH;
J Am Coll Nutr. 2001;20:398S-402S
Effects of flaxseed supplementation on bone metabolism in
postmenopausal women
Arjmandi, B,H., Juma, S., Lucas, E.A., Wei
L.L., Venkatesh, S., Khan, D.A.; Proc Flax Inst N Am. 57: 65-74,
1998.
Other
Higher dietary intake of lignans is associated with better
cognitive performance in postmenopausal women
Franco OH, Burger
H, Lebrun CEI, Peeters PHM, Lamberts SWJ, Grobbee DE, Van Der Schouw YT; J.
Nutr. 2005 May, 135:1190-1195
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